What is VBE Vanillyl Butyl Ether CAS 82654-98-6?

VBE Vanillyl Butyl Ether CAS 82654-98-6 is a synthetic warming and sensorial cosmetic ingredient. Its INCI name is Vanillyl Butyl Ether, and its chemical name is 4-(butoxymethyl)-2-methoxyphenol, with the molecular formula C12H18O3 and molecular weight 210.27 g/mol. It is normally supplied as a colorless to pale yellow liquid.

How does Vanillyl Butyl Ether create a warming effect compared with capsaicin?

It interacts with the TRPV1 sensory pathway in the skin, producing a perception of warmth rather than directly heating tissue. Compared with capsaicin, it is generally considered much less irritating and offers a more balanced, cosmetic-friendly warming sensation for leave-on products.

What cosmetic applications is VBE suitable for?

VBE is commonly used in body-shaping and slimming creams, anti-cellulite lotions, warming massage products, scalp and hair-care formulations, foot-care products, and fragrance or oral-care applications. It works as an oil-soluble sensorial active that can be incorporated into emulsion, oil, or solvent-based systems.

What are the key formulation properties of Vanillyl Butyl Ether?

It is soluble in ethanol, propylene glycol, oils, and most organic solvents, while it is only slightly soluble or practically insoluble in water. Typical values include a boiling point around 241 C, density around 1.057 g/mL at 25 C, refractive index about 1.511-1.521 at 20 C, and a flash point above 100 C.

What safety and handling points should formulators confirm before use?

Formulators should treat VBE as a possible serious eye irritant and weak skin sensitizer; some users may develop an allergic skin reaction. Avoid claims that it is non-irritating or suitable for everyone, and use appropriate skin patch testing and regulatory review for each finished formulation.

VBE Vanillyl Butyl Ether CAS 82654-98-6

VBE Vanillyl Butyl Ether (CAS 82654-98-6) is an advanced oil-soluble sensory agent functioning as a mild, long-lasting warming ingredient in personal care and cosmetic formulations. Chemically identified as 4-(Butoxymethyl)-2-methoxyphenol, this colorless to pale yellow liquid acts to stimulate nerve receptors in the skin to produce a sensation of heat without the redness or stinging irritation associated with traditional capsaicin. As a stable Vanillyl alcohol ether derivative, it is extensively utilized in slimming creams, massage oils, and scalp treatments to enhance blood microcirculation and accelerate metabolism. We ensure bulk supply capabilities for this material, providing access to competitive factory pricing and customized specifications to meet specific purity standards (typically >98% or >99%). Full technical documentation, including MSDS, TDS, COA, is available to support compliance and safety protocols.

CAS: 82654-98-6
Synonyms: 4-(Butoxymethyl)-2-methoxyphenol, Vanillyl butyl ether, Butyl vanillyl ether, VBE warming agent
Einecs: 444-010-7
Molecular Formula: C12H18O3
Grade: Cosmetic Grade / Food Grade
Package: 1kg Aluminum Bottle, 5kg, or 25kg Plastic Drum

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Product Description

VBE acts by stimulating the nerve endings (TRPV1 receptors) in the skin to produce a sensation of heat.

Key Advantages:

Low Irritation: Compared to Capsicum oleoresin or Synthetic Capsaicin, VBE is much less irritating to the skin and has a lower allergenic potential.
Rapid & Lasting Effect: It induces a warming sensation within 5 minutes of application, which can last for several hours.
Stability: It is chemically stable and easy to emulsify in various cosmetic formulations.
Fragrance Enhancement: Due to its vanillyl structure, it adds a pleasant, subtle vanilla note to the final product.

1 Physicochemical Properties

2 Applications

3 Storage Conditions

4 Safety Precautions

Physicochemical Properties

Test Item	Specification (Standard)
Appearance	Colorless to pale yellow liquid
Odor	Weak, characteristic vanilla-like odor
Assay (GC Purity)	≥ 98.0% (Standard) / ≥ 99.0% (Premium)
Refractive Index (20°C)	1.511 – 1.521
Specific Gravity (20°C)	1.052 – 1.072 g/cm³
Acid Value	≤ 1.0 mgKOH/g
Color (Hazen/APHA)	≤ 80
Boiling Point	Approx. 241°C
Flash Point	> 100°C
Solubility	Soluble in oil, ethanol, and most organic solvents; Slightly soluble in water

Applications

Body Shaping & Slimming: A key ingredient in slimming creams, lotions, and anti-cellulite products to promote blood circulation and metabolism.
Pain Relief: Used in topical analgesic patches, ointments, and muscle rub gels to relieve joint pain and muscle stiffness through heat therapy.
Personal Care:
- Lip Care: Used in lip plumpers and glosses to create a tingling sensation and volumizing effect.
- Massage: Essential ingredient in warming massage oils and foot bath products.
- Hair Care: Added to scalp treatments to stimulate follicles.
Food Industry: Approved as a flavoring agent (FEMA 3796) to provide vanilla notes and heat sensation.

Recommended Dosage:

Lips: 0.1% – 0.3%
Body products: 0.2% – 1.0%

Storage Conditions

Temperature: Store in a cool place (below 25°C). However, do not freeze.
Oxidation Control: VBE can turn yellow if oxidized. It is strictly recommended to keep it in tightly sealed containers, preferably with Nitrogen blanketing if opened.
Light: Protect from direct sunlight and strong UV sources.
Shelf Life: 24 months in original unopened packaging.

Safety Precautions

Handling: VBE is a concentrated warming agent. Do not apply pure VBE directly to the skin. It causes a strong burning sensation in its concentrated form.
Protective Equipment: Wear protective gloves (nitrile) and safety goggles when handling the raw material.
In Case of Contact:
- Skin: If concentrated liquid touches skin, do not wash with water immediately (it spreads the oil). Wash first with mineral oil or vegetable oil to dilute it, then wash with soap and water.
- Eyes: Rinse cautiously with water for several minutes and seek medical help.

FAQ - Technical & Supply Chain

Q:
What is VBE Vanillyl Butyl Ether CAS 82654-98-6?

A: VBE Vanillyl Butyl Ether CAS 82654-98-6 is a synthetic warming and sensorial cosmetic ingredient. Its INCI name is Vanillyl Butyl Ether, and its chemical name is 4-(butoxymethyl)-2-methoxyphenol, with the molecular formula C12H18O3 and molecular weight 210.27 g/mol. It is normally supplied as a colorless to pale yellow liquid.
Q:
How does Vanillyl Butyl Ether create a warming effect compared with capsaicin?

A: It interacts with the TRPV1 sensory pathway in the skin, producing a perception of warmth rather than directly heating tissue. Compared with capsaicin, it is generally considered much less irritating and offers a more balanced, cosmetic-friendly warming sensation for leave-on products.
Q:
What cosmetic applications is VBE suitable for?

A: VBE is commonly used in body-shaping and slimming creams, anti-cellulite lotions, warming massage products, scalp and hair-care formulations, foot-care products, and fragrance or oral-care applications. It works as an oil-soluble sensorial active that can be incorporated into emulsion, oil, or solvent-based systems.
Q:
What are the key formulation properties of Vanillyl Butyl Ether?

A: It is soluble in ethanol, propylene glycol, oils, and most organic solvents, while it is only slightly soluble or practically insoluble in water. Typical values include a boiling point around 241 C, density around 1.057 g/mL at 25 C, refractive index about 1.511-1.521 at 20 C, and a flash point above 100 C.
Q:
What safety and handling points should formulators confirm before use?

A: Formulators should treat VBE as a possible serious eye irritant and weak skin sensitizer; some users may develop an allergic skin reaction. Avoid claims that it is non-irritating or suitable for everyone, and use appropriate skin patch testing and regulatory review for each finished formulation.

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