What is 2-Iodo-4-nitroaniline CAS 6293-83-0?

2-Iodo-4-nitroaniline is a halogenated nitroaromatic amine with the molecular formula C6H5IN2O2 and a molecular weight of about 264.02. It is normally supplied as a light yellow to brown powder or crystal and is commonly listed as an industrial or synthesis-grade intermediate.

What are the main uses of 2-Iodo-4-nitroaniline?

It is primarily used as an aryl iodide-containing intermediate for multistep pharmaceutical, fine-chemical, and dye-related synthesis. The amino, nitro, and iodine sites allow reduction, diazotization, substitution, and coupling-oriented transformations to build more complex aromatic structures.

What are typical specifications for CAS 6293-83-0?

Commercial material is often specified with an assay of at least 98% by GC and a melting point near 105-109 C. Other reference data include a predicted boiling point around 377.6 C, density about 2.278 g/cm3, and solubility in methanol with low water solubility.

How is 2-Iodo-4-nitroaniline different from 4-iodo-2-nitroaniline?

The two compounds are positional isomers. In 2-Iodo-4-nitroaniline the iodine is at the 2-position and the nitro group is at the 4-position, while 4-iodo-2-nitroaniline has the reverse arrangement. Buyers should confirm CAS 6293-83-0 and batch identity data such as NMR or chromatography before use.

How should 2-Iodo-4-nitroaniline CAS 6293-83-0 be stored?

Store it tightly closed in a cool, dark, well-ventilated area and protect it from direct light. Because the material is light and air sensitive, many suppliers recommend inert-gas or refrigerated storage at 2-8 C; use appropriate PPE and avoid dust formation during handling.

2-Iodo-4-nitroaniline CAS 6293-83-0

2-Iodo-4-nitroaniline is an iodinated nitroaniline compound used in chemical intermediates and fine synthesis workflows, and this aromatic building block is also referenced in technical records as 2-Iodo-4-nitrobenzenamine, 2-Iodo-4-nitrophenylamine, 4-Amino-3-iodonitrobenzene, and Benzenamine, 2-iodo-4-nitro-, with CAS 6293-83-0 used to confirm substance identity. Its structure combines an aniline amino group with a nitro substituent and an activated aryl iodine site, so it is commonly handled as a synthesis intermediate for substitution, reduction, and cross-coupling steps in pharmaceutical intermediate development, laboratory route design, and fine chemical manufacturing processes where controlled aromatic functionalization is required. This material is offered with competitive factory pricing, customized specifications, document support including MSDS, TDS, COA, and options for bulk supply.

CAS: 6293-83-0
Synonyms: 2-Iodo-4-nitrobenzenamine; 2-Iodo-4-nitrophenylamine; 4-Amino-3-iodonitrobenzene; Benzenamine, 2-iodo-4-nitro-; 2-Iodo-4-nitroaniline
Einecs: 627-788-4
Molecular Formula: C6H5IN2O2
Grade: Industrial / Synthesis Grade
Package: Commonly supplied in small packs for evaluation and scalable custom packing for industrial handling

Request a quote

Share:

Product Description

Technical Data

Item	Specification / Reference Data
Appearance	Light yellow to brown powder to crystal
Assay	Typically ≥98.0% (GC); some commercial grades 97–99%
Molecular Formula	C6H5IN2O2
Molecular Weight	264.02
Physical State (20°C)	Solid
Melting Point	105–109°C (literature / commercial reference); some suppliers list about 107°C
Boiling Point	377.6±27.0°C (predicted)
Density	2.278 g/cm³
Solubility	Soluble in methanol; generally handled as a low-water-solubility aromatic solid
λmax	360 nm (MeOH)
pKa	-1.18±0.10 (predicted)
Storage	Keep in dark place; store under inert atmosphere; 2–8°C or cool and dark conditions
Sensitivity	Light sensitive; air sensitivity

Applications

Pharmaceutical intermediate synthesis: used as an aryl iodide-containing intermediate for further coupling, reduction, and ring-functionalization steps in multistep synthesis.
Fine chemical synthesis: suitable for building substituted aromatic amine structures in route scouting and custom synthesis programs.
Research and process development: used in laboratory-scale reaction design where a halogenated nitroaniline scaffold is needed for downstream transformation. This is an inference from its documented structure and intermediate role.

Storage & Safety

Store the material in a tightly closed container in a cool, dry, and well-ventilated area. Light protection is recommended, and several commercial references also advise storage under inert gas; refrigerated storage at 2–8°C is commonly cited for stability control, while other sources specify a cool dark place below 15°C. During handling, use chemical-resistant gloves, protective eyewear, and suitable protective clothing. Avoid dust formation and direct contact with skin and eyes. For process areas, local exhaust ventilation is recommended. Reported hazard statements include skin irritation and serious eye irritation, and some commercial listings also include respiratory irritation language, so routine industrial PPE and closed handling practice are appropriate.

Quality Assurance

For industrial supply, a practical quality control program usually focuses on identity, purity, and batch consistency. Typical release items can include GC or HPLC assay, appearance check, melting point verification, and structure confirmation by NMR against reference data; some commercial specification pages also note NMR confirmation to structure as part of quality documentation practice. If a buyer needs a higher compliance route such as GMP-linked manufacturing, that point should be confirmed case by case rather than assumed by default.

FAQ - Technical & Supply Chain

Q:
What is 2-Iodo-4-nitroaniline CAS 6293-83-0?

A: 2-Iodo-4-nitroaniline is a halogenated nitroaromatic amine with the molecular formula C6H5IN2O2 and a molecular weight of about 264.02. It is normally supplied as a light yellow to brown powder or crystal and is commonly listed as an industrial or synthesis-grade intermediate.
Q:
What are the main uses of 2-Iodo-4-nitroaniline?

A: It is primarily used as an aryl iodide-containing intermediate for multistep pharmaceutical, fine-chemical, and dye-related synthesis. The amino, nitro, and iodine sites allow reduction, diazotization, substitution, and coupling-oriented transformations to build more complex aromatic structures.
Q:
What are typical specifications for CAS 6293-83-0?

A: Commercial material is often specified with an assay of at least 98% by GC and a melting point near 105-109 C. Other reference data include a predicted boiling point around 377.6 C, density about 2.278 g/cm3, and solubility in methanol with low water solubility.
Q:
How is 2-Iodo-4-nitroaniline different from 4-iodo-2-nitroaniline?

A: The two compounds are positional isomers. In 2-Iodo-4-nitroaniline the iodine is at the 2-position and the nitro group is at the 4-position, while 4-iodo-2-nitroaniline has the reverse arrangement. Buyers should confirm CAS 6293-83-0 and batch identity data such as NMR or chromatography before use.
Q:
How should 2-Iodo-4-nitroaniline CAS 6293-83-0 be stored?

A: Store it tightly closed in a cool, dark, well-ventilated area and protect it from direct light. Because the material is light and air sensitive, many suppliers recommend inert-gas or refrigerated storage at 2-8 C; use appropriate PPE and avoid dust formation during handling.

Ordering & Documentation

Key information for document requests, quotations, and supply planning.

Documents

COA, TDS, SDS/MSDS and packing details are available on request.

Quotation

Send the CAS number, grade, quantity, packing preference and destination.

Sample & Supply

Support is available for samples, trial orders, bulk and repeat supply.

Storage & Shipping

Product-specific conditions are confirmed before order.

Current Language

Change Language