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    HomeProductsBasic & Fine ChemicalsChemical Intermediates2-Iodo-4-nitroaniline CAS 6293-83-0
    • 2-Iodo-4-nitroaniline CAS 6293-83-0
    • 2-Iodo-4-nitroaniline CAS 6293-83-0

    2-Iodo-4-nitroaniline CAS 6293-83-0

    2-Iodo-4-nitroaniline is an iodinated nitroaniline compound used in chemical intermediates and fine synthesis workflows, and this aromatic building block is also referenced in technical records as 2-Iodo-4-nitrobenzenamine, 2-Iodo-4-nitrophenylamine, 4-Amino-3-iodonitrobenzene, and Benzenamine, 2-iodo-4-nitro-, with CAS 6293-83-0 used to confirm substance identity. Its structure combines an aniline amino group with a nitro substituent and an activated aryl iodine site, so it is commonly handled as a synthesis intermediate for substitution, reduction, and cross-coupling steps in pharmaceutical intermediate development, laboratory route design, and fine chemical manufacturing processes where controlled aromatic functionalization is required. This material is offered with competitive factory pricing, customized specifications, document support including MSDS, TDS, COA, and options for bulk supply.

    • CAS: 6293-83-0
    • Synonyms: 2-Iodo-4-nitrobenzenamine; 2-Iodo-4-nitrophenylamine; 4-Amino-3-iodonitrobenzene; Benzenamine, 2-iodo-4-nitro-; 2-Iodo-4-nitroaniline
    • Einecs: 627-788-4
    • Molecular Formula: C6H5IN2O2
    • Grade: Industrial / Synthesis Grade
    • Package: Commonly supplied in small packs for evaluation and scalable custom packing for industrial handling
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    Product Description

    1 Technical Data
    2 Applications
    3 Storage & Safety
    4 Quality Assurance

    Technical Data

    ItemSpecification / Reference Data
    AppearanceLight yellow to brown powder to crystal
    AssayTypically ≥98.0% (GC); some commercial grades 97–99%
    Molecular FormulaC6H5IN2O2
    Molecular Weight264.02
    Physical State (20°C)Solid
    Melting Point105–109°C (literature / commercial reference); some suppliers list about 107°C
    Boiling Point377.6±27.0°C (predicted)
    Density2.278 g/cm³
    SolubilitySoluble in methanol; generally handled as a low-water-solubility aromatic solid
    λmax360 nm (MeOH)
    pKa-1.18±0.10 (predicted)
    StorageKeep in dark place; store under inert atmosphere; 2–8°C or cool and dark conditions
    SensitivityLight sensitive; air sensitivity

    Applications

    • Pharmaceutical intermediate synthesis: used as an aryl iodide-containing intermediate for further coupling, reduction, and ring-functionalization steps in multistep synthesis.
    • Fine chemical synthesis: suitable for building substituted aromatic amine structures in route scouting and custom synthesis programs.
    • Research and process development: used in laboratory-scale reaction design where a halogenated nitroaniline scaffold is needed for downstream transformation. This is an inference from its documented structure and intermediate role.

    Storage & Safety

    Store the material in a tightly closed container in a cool, dry, and well-ventilated area. Light protection is recommended, and several commercial references also advise storage under inert gas; refrigerated storage at 2–8°C is commonly cited for stability control, while other sources specify a cool dark place below 15°C. During handling, use chemical-resistant gloves, protective eyewear, and suitable protective clothing. Avoid dust formation and direct contact with skin and eyes. For process areas, local exhaust ventilation is recommended. Reported hazard statements include skin irritation and serious eye irritation, and some commercial listings also include respiratory irritation language, so routine industrial PPE and closed handling practice are appropriate.

    Quality Assurance

    For industrial supply, a practical quality control program usually focuses on identity, purity, and batch consistency. Typical release items can include GC or HPLC assay, appearance check, melting point verification, and structure confirmation by NMR against reference data; some commercial specification pages also note NMR confirmation to structure as part of quality documentation practice. If a buyer needs a higher compliance route such as GMP-linked manufacturing, that point should be confirmed case by case rather than assumed by default.

    FAQ - Technical & Supply Chain

    • Q:

      How can buyers distinguish 2-Iodo-4-nitroaniline from positional isomers such as 4-Iodo-2-nitroaniline?

      A: The distinction should be confirmed by the assigned CAS number, the substitution pattern on the aromatic ring, and batch identity data such as NMR or chromatographic results. For this product, the accepted identity is 2-Iodo-4-nitroaniline with CAS 6293-83-0.
    • Q:

      Is 2-Iodo-4-nitroaniline typically selected for direct formulation use or for multistep synthesis?

      A: It is typically selected for multistep synthesis. In industrial practice, it is more commonly treated as a halogenated aromatic intermediate used for further transformation rather than as a direct-use formulation ingredient.
    • Q:

      What is the common functional role of this material in a synthesis route?

      A: It is commonly used as an aromatic intermediate that combines an amino group, a nitro group, and an aryl iodine site in one molecule, which makes it suitable for downstream reduction, substitution, and coupling-oriented route design. This is a structure-based synthesis interpretation supported by its intermediate classification.
    Documents

    Documents and Product Support

    For product review and sourcing evaluation, supporting documents can be coordinated according to the product type, inquiry stage, and order requirements.

    • COA for batch-based quality reference
    • TDS for key physical and chemical information
    • SDS / MSDS for handling, storage, and safety reference
    • Packing information for sample, trial, and bulk orders
    • Technical communication based on application and specification requirements
    Quotation

    Information to Confirm Before Quotation

    Clear sourcing information helps reduce specification mismatch and allows a more accurate quotation before sample or bulk order discussion.

    • Product name and CAS number
    • Application or intended end use
    • Required purity, grade, or specification
    • Sample quantity, trial order, or bulk demand
    • Preferred packing form or net weight
    • Destination country or port
    • Required documents or compliance expectations
    Storage & Handling

    Packaging, Storage, and Handling Notes

    Packaging form, storage conditions, shelf life, and shipment arrangements should be confirmed according to the product characteristics, package size, and destination requirements.

    Before order confirmation, buyers are advised to review the corresponding product documents and confirm whether any special storage, labeling, or handling requirements apply.

    Supply Support

    Sample, Bulk Order and Repeat Supply Support

    Support can be arranged for sample discussion, bulk supply planning, packaging confirmation, and routine sourcing communication based on the actual product and order requirements.

    For repeat-use formulations or long-term procurement plans, buyers may discuss specification consistency, packaging preferences, delivery expectations, and document coordination in advance.

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    Dye Intermediate Fine Chemical Intermediate Halogenated Aromatic Nitroaniline Intermediate

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